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    (For the treatment of lip sores and mouth ulcers)
    A number of clinical studies have established the therapeutic efficacy of topically applied Carbenoxolone Sodium in the form of gels, creams or mouthwashes in the treatment of lip and cold sores, mouth ulcers or other apthae changes in the oral mucous membranes.
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Carbosan Gel

hst3Composition

Carbosan gel contains Carbenoxolone Sodium B.P. 2% w/w

 

carbosanhst3Mode of Action

Carbenoxolone Sodium is a derivative of enoxolone. It possesses anti-inflammatory and anti-diuretic properties and has been shown in clinical trials to have excellent healing properties, providing rapid relief of pain and curtailing development of lesions.

The Biological and Pharmacological properties associated with Carbenoxolone Sodium which justify the proposed therapeutic use of CARBOSAN are: -

 

 

- The proven ability of Carbenoxolone Sodium over many years of clinical use to promote the healing of gastric,
  duodenal and mouth ulcers.

- Carbenoxolone Sodium when applied to gastric mucosa has been shown to acts by strengthening the
  epithelial mucosa, a barrier which provides the first and second line of defence against injury.

- Carbenoxolone Sodium has anti-inflammatory properties.

- Carbenoxolone Sodium increase mucosal blood flow and the local cytoprotective prostaglandins.

- Carbenoxolone Sodium and related compounds have been shown to have anti-viral activity against a wide
  spectrum of viruses including herpes and adenovirus. Recently interest has heightened in the growing
  evidence linking ulceration and viral infection.

 

hst3Clinical Results

cdc_cold_sore_closeup_lipsA number of clinical studies have established the therapeutic efficacy of topically applied Carbenoxolone Sodium in the form of gels, creams or mouthwashes in the treatment of lip and cold sores, mouth ulcers or other apthae changes in the oral mucous membranes. In a high percentage of patients, pain was reduced, and the lesions healed more quickly

There was reduction in the average number of ulcers or lesions per day, the development of new ulcers and the number of lesion free days. Carbenoxolone Sodium appeared to be of value where there was recurrent infection.

Niebauer, found CARBOSAN gel to be a valuable addition to the therapy of recurrent herpes simplex infections and in recurrent apthae changes in the oral mucous membranes giving excellent clinical response in 93% of the patients treated.

Poswillo, et.al used Carbenoxolone Sodium in mouthwash from and found it to be remarkably effective against acute herpetic stomatitis and recurrent herpes febrilis, conditions which do not respond quickly and completely to large range of topical anti-viral agents.

Poswillo, et.al using Carbenoxolone Sodium mouthwash in a double blind cross-over trial found that treatment reduced the average number of ulcers per day, the number of new ulcers developing and discomfort and pain associated with lesions

Carbosan Gel - ANTI-VIRAL

hst3Anti-Viral Activity of Carbenoxolone Sodium and Relate Substances

dermnet_herpes_with_canker_sore_insetIt has been established that substances present in Glycyrrhiza glabra and near analogues, including Carbenoxolone Sodium have anti-viral activity.

Glycarrhizic acid has been shown to be effective in inhibiting both growth and cytopathic effects of vaccinia, herpes simplex Newcastle disease and vesicular stomatitis virus.

Carbenoxolone Sodium has been shown to have anti-viral activity against a wide spectrum of viruses including herpes and adenovirus.

The possible relationship between ulceration and virus has been emphasized.

 

hst3Indications

For the treatments of lip sores, cold sores and other such orofacial lesions caused by Herpes Simplex, Herpas Labialis and Herpes Febrillis.

For the treatement of Aphthous ulceration of the oral mucous membranes, mouth ulcers.

 

hst3Contra-Indications, Warnings

Carbosan gel should not be used during pregnancy or lactation. The product should not b used in the elderly or in patients with low serum albumin.

Carbosan is contraindicated in patients suffering from severe cardiac, renal and hepatic impairment, patients with hypertension, or those who receiving cardiac glycosides. If bacterial infection is superimposed, appropriate therapy should be given.

 

hst3Side and Adverse Effects

No side effects have been reported with the use of Carbosan gel. If symptoms persist for more than two weeks, a physician should be consulted.

 

hst3Dosages and Administration

Carbosan Gel is for Topical Use only.
Adults and Children over 3 years:

Apply thickly to lesions four times daily, preferably after meals and at bedtime. The gel should be applied at the first symptoms (tingling of burning sensation) of a lip sore or mouth ulcer. The gel should be allowed to remain on the affected area for as long as possible.

Expectant mothers and children under 3 years should first consult their physician before using any medication.

 

hst3Presentation

A translucent colourless gel.
Tube of 5g.

 

hst3Pharmaceutical Precautions

Store below 25°C.
The cap should be replaced immediately after use.
Keep all medicines out of the reach of children.

 

hst3Carbosan Gel

Ensures:

- Rapid Healing

- Management of viral infection

- Decrease in severity of symptoms

- Curtailed period of infection

- Decreased possibility of secondary infection

- Prolongs recurrence-free intervals

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